SUP-T1

SUP-T1/SUP-T1细胞系/SUP-T1细胞株/SUP-T1人T淋巴瘤细胞

Cell line name SUP-T1

Synonyms Sup-T1; SUPT-1; SupT-1; Sup T-1; SUP T-1; SUP T1; Sup T1; SupT1; SUPT1; Tsup-1; VB; Stanford University Pediatric T-cell line 1

Accession CVCL_1714

Resource Identification Initiative To cite this cell line use: SUP-T1 (RRID:CVCL_1714)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Population: Caucasian.

Characteristics: Has chromosomal translocations involving the genes for the alpha and beta subunits of TCR thus preventing surface expression of the endogenous TCR complex.

Virology: Useful for studies of cell fusion and cytopathic effects of HIV-1 as well as cytopathic isolates of HIV-2.

Virology: Susceptible to infection by herpesvirus 6B (HHV-6B) strain Z29 (PubMed=29304865).

Doubling time: 28 hours (PubMed=3004618); ~30 hours (DSMZ=ACC-140); ~24-36 hours (BEI_Resources=ARP-100).

Microsatellite instability: Stable (MSS) (Sanger).

Microsatellite instability: Instable (MSI) (PubMed=31068700).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Omics: Virome analysis using RNAseq.

Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.

Cell type: T-cell; CL=CL_0000084.

PubMed=3107838; DOI=10.1016/0092-8674(87)90542-3

Stein B.S., Gowda S.D., Lifson J.D., Penhallow R.C., Bensch K.G., Engleman E.G.

pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane.

Cell 49:659-668(1987)

 

PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893

Stranks G., Height S.E., Mitchell P., Jadayel D.M., Yuille M.A.R., De Lord C.F.M., Clutterbuck R.D., Treleaven J.G., Powles R.L., Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D., Millar J.L., Catovsky D., Dyer M.J.S.

Deletions and rearrangement of CDKN2 in lymphoid malignancy.

Blood 85:893-901(1995)

 

PubMed=8558920

Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M., Quentmeier H., Drexler H.G.

The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.

Leukemia 10:142-149(1996)

 

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7

Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.

Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.

Leuk. Res. 23:19-27(1999)

 

DOI=10.1016/B978-0-12-221970-2.50457-5

Drexler H.G.

The leukemia-lymphoma cell line factsbook.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

 

PubMed=11264379; DOI=10.1128/JVI.75.8.3903-3915.2001; PMCID=PMC114881

Means R.E., Matthews T., Hoxie J.A., Malim M.H., Kodama T., Desrosiers R.C.

Ability of the V3 loop of  serve as a target for antibody-mediated neutralization: correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4.

J. Virol. 75:3903-3915(2001)

 

PubMed=17170727; DOI=10.1038/sj.leu.2404486

Sandberg Y., Verhaaf B., van Gastel-Mol E.J., Wolvers-Tettero I.L.M., De Vos J., MacLeod R.A.F., Noordzij J.G., Dik W.A., van Dongen J.J.M., Langerak A.W.

Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.

Leukemia 21:230-237(2007)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=22292511; DOI=10.2174/187221512799303172

Ho P., Dai K.-S., Chen H.-L.

Molecular cloning of a novel PPEF-1 gene variant from a T-cell lymphoblastic lymphoma cell line.

Recent Pat. DNA Gene Seq. 6:72-77(2012)