SW780

SW780/SW780细胞系/SW780细胞株/SW780人膀胱移行细胞癌

Cell line name SW780

Synonyms SW-780; SW 780

Accession CVCL_1728

Resource Identification Initiative To cite this cell line use: SW780 (RRID:CVCL_1728)

Comments Part of: BLA-40 bladder carcinoma cell line panel.

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: TCGA-110-CL cell line panel.

Part of: UBC-40 urothelial bladder cancer cell line index.

From: Scott and White Clinic; Temple; USA.

Population: Caucasian.

Microsatellite instability: Stable (MSS) (Sanger).

Omics: CNV analysis.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.

Sequence variations

Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=24035680).

HLA typing Source: PubMed=26589293

Class I

HLA-A A*03:01,23:01

HLA-B B*07:02,41:02

HLA-C C*07:02,17:01

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0.52

Native American 0.16

East Asian, North 0.43

East Asian, South 0.73

South Asian 3.11

European, North 68.95

European, South 26.09

Disease Bladder carcinoma (NCIt: C4912)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Children:

CVCL_C3GV (SW780 FOXP3) CVCL_C3GW (SW780 FOXP3Delta3) CVCL_E1CI (Ubigene SW780 NECTIN4 KO)

Sex of cell Female

Age at sampling 80Y

Category Cancer cell line

STR profile Source(s): ATCC=CRL-2169; Cosmic-CLP=687457; PubMed=25877200; PubMed=27270441

 

Markers:

Amelogenin X

CSF1PO 10,11

D2S1338 19,22

D3S1358 16,18

D5S818 11,12

D7S820 9,10

D8S1179 13

D13S317 11,12

D16S539 9,11

D18S51 15

D19S433 13,15

D21S11 29,30

FGA 19,20

Penta D 9

Penta E 12

TH01 6

TPOX 8

vWA 16 (PubMed=27270441)

16,19 (ATCC=CRL-2169; Cosmic-CLP=687457; PubMed=25877200)

 

Run an STR similarity search on this cell line

Publications

PubMed=833871; DOI=10.1093/jnci/58.2.209

Fogh J., Wright W.C., Loveless J.D.

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

J. Natl. Cancer Inst. 58:209-214(1977)

 

PubMed=924690; DOI=10.1002/ijc.2910200505

Kerbel R.S., Pross H.F., Leibovitz A.

Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.

Int. J. Cancer 20:673-679(1977)

 

PubMed=571047

Fogh J.

Cultivation, characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors.

Natl. Cancer Inst. Monogr. 49:5-9(1978)

 

PubMed=6244232

Williams R.D.

Human urologic cancer cell lines.

Invest. Urol. 17:359-363(1980)

 

PubMed=7459858

Rousset M., Zweibaum A., Fogh J.

Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.

Cancer Res. 41:1165-1170(1981)

 

PubMed=6744315

Kyriazis A.A., Kyriazis A.P., McCombs W.B. 3rd, Peterson W.D. Jr.

Morphological, biological, and biochemical characteristics of human bladder transitional cell carcinomas grown in tissue culture and in nude mice.

Cancer Res. 44:3997-4005(1984)

 

PubMed=3518877; DOI=10.3109/07357908609038260

Fogh J.

Human tumor lines for cancer research.

Cancer Invest. 4:157-184(1986)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)