TMK-1

TMK-1细胞TMK-1细胞TMK-1;人胃癌细胞

Cell line name TMK-1

Synonyms TMK1

Accession CVCL_4384

Resource Identification Initiative To cite this cell line use: TMK-1 (RRID:CVCL_4384)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Population: Japanese.

Doubling time: ~34.9 hours (PubMed=3003017).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: Transcriptome analysis by microarray.

Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.

Sequence variations

Mutation; HGNC; 11998; TP53; Simple; p.Val173Met (c.517G>A); ClinVar=VCV000233951; Zygosity=Unspecified (PubMed=1370612; PubMed=1933850; PubMed=11107048).

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0.05

Native American 0.49

East Asian, North 70.76

East Asian, South 27.97

South Asian 0

European, North 0.73

European, South 0

Disease Gastric adenocarcinoma (NCIt: C4004)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Parent: CVCL_F953 (SC-6-JCK)

Sex of cell Male

Age at sampling 21Y

Category Cancer cell line

STR profile Source(s): Cosmic-CLP=1299069

 

Markers:

Amelogenin X

CSF1PO 10,12

D5S818 10,13

D7S820 8,12

D13S317 10,13

D16S539 9

TH01 9

TPOX 8,10

vWA 14

 

Run an STR similarity search on this cell line

Publications

PubMed=3003017; DOI=10.20772/cancersci1985.76.11_1064

Ochiai A., Yasui W., Tahara E.

Growth-promoting effect of gastrin on human gastric carcinoma cell line TMK-1.

Jpn. J. Cancer Res. 76:1064-1071(1985)

 

PubMed=1933850

Yamada Y., Yoshida T., Hayashi K., Sekiya T., Yokota J., Hirohashi S., Nakatani K., Nakano H., Sugimura T., Terada M.

p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.

Cancer Res. 51:5800-5805(1991)

 

PubMed=1370612; DOI=10.1016/S0006-291X(05)80133-0

Matozaki T., Sakamoto C., Matsuda K., Suzuki T., Konda Y., Nakano O., Wada K., Uchida T., Nishisaki H., Nagao M., Kasuga M.

Missense mutations and a deletion of the p53 gene in human gastric cancer.

Biochem. Biophys. Res. Commun. 182:215-223(1992)

 

DOI=10.1016/B978-0-12-333530-2.50014-9

Sekiguchi M., Suzuki T.

Gastric tumor cell lines.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994)

 

PubMed=11107048; DOI=10.1046/j.1440-1827.2000.01117.x

Yokozaki H.

Molecular characteristics of eight gastric cancer cell lines established in Japan.

Pathol. Int. 50:767-777(2000)

 

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469

Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Miro, Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

A landscape of pharmacogenomic interactions in cancer.

Cell 166:740-754(2016)

 

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

 

PubMed=30971826; DOI=10.1038/s41586-019-1103-9

Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Nature 568:511-516(2019)

 

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775

Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Pan-cancer proteomic map of 949 human cell lines.

Cancer Cell 40:835-849.e8(2022)