COV434

COV434/COV434细胞系/COV434细胞株/COV434人卵巢颗粒肿瘤细胞

Cell line name COV434

Synonyms COV-434; COV 434

Accession CVCL_2010

Resource Identification Initiative To cite this cell line use: COV434 (RRID:CVCL_2010)

Comments Problematic cell line: Misclassified. Originally thought to be an ovarian granulosa cell tumor but seems to be a small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) (PubMed=33328126).

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Population: Caucasian.

Characteristics: Because it conserved a number of properties of normal human granulosa cells, it is used in the investigation of such cell type.

Doubling time: 24 hours (PubMed=25984343).

Omics: Deep exome analysis.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.

Sequence variations

Mutation; HGNC; 11100; SMARCA4; Simple; c.3952-1G>C; ClinVar=VCV000635379; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=33328126; DepMap=ACH-000123).

HLA typing Source: PubMed=26589293

Class I

HLA-A A*02:05,31:01

HLA-B B*44:02,50:01

HLA-C C*06:02,15:02

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 1.5

Native American 0.68

East Asian, North 0.76

East Asian, South 0

South Asian 0

European, North 60.55

European, South 36.51

Disease Ovarian small cell carcinoma, hypercalcemic type (NCIt: C40439)

Small cell carcinoma of the ovary (ORDO: Orphanet_370396)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell Female

Age at sampling 26Y

Category Cancer cell line

STR profile Source(s): ECACC=07071909; PubMed=25877200

 

Markers:

Amelogenin X

CSF1PO 10,11

D3S1358 15,19

D5S818 10,11

D7S820 8

D8S1179 13,14

D13S317 8,12

D16S539 9,12

D18S51 10,15

D21S11 28

FGA 24,25

Penta D 10,12

Penta E 12

TH01 9.3

TPOX 9,11

vWA 16,18

 

Run an STR similarity search on this cell line

Publications

PubMed=8436435; DOI=10.1002/ijc.2910530415

van den Berg-Bakker C.A.M., Hagemeijer A., Franken-Postma E.M., Smit V.T.H.B.M., Kuppen P.J.K., van Ravenswaay Claasen H.H., Cornelisse C.J., Schrier P.I.

Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: growth features and cytogenetics.

Int. J. Cancer 53:613-620(1993)

 

PubMed=9413942; DOI=10.1038/bjc.1997.597; PMCID=PMC2228215

Brouwenstijn N., Slager E.H., Bakker A.B.H., Schreurs M.W.J., van der Spek C.W., Adema G.J., Schrier P.I., Figdor C.G.

Transcription of the gene encoding melanoma-associated antigen gp100 in tissues and cell lines other than those of the melanocytic lineage.

Br. J. Cancer 76:1562-1566(1997)

 

PubMed=15541573; DOI=10.1016/j.mce.2004.04.018

Havelock J.C., Rainey W.E., Carr B.R.

Ovarian granulosa cell lines.

Mol. Cell. Endocrinol. 228:67-78(2004)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

 

PubMed=23839242; DOI=10.1038/ncomms3126; PMCID=PMC3715866

Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.

Evaluating cell lines as tumour models by comparison of genomic profiles.

Nat. Commun. 4:2126.1-2126.10(2013)

 

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652

Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Sci. Data 1:140035-140035(2014)

 

PubMed=25485619; DOI=10.1038/nbt.3080

Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.

A comprehensive transcriptional portrait of human cancer cell lines.

Nat. Biotechnol. 33:306-312(2015)

 

PubMed=25877200; DOI=10.1038/nature14397

Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.

A resource for cell line authentication, annotation and quality control.

Nature 520:307-311(2015)

 

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878

Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Genome Med. 7:118.1-118.7(2015)

 

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

 

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103

Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Nature 569:503-508(2019)

 

PubMed=33328126; DOI=10.1016/j.ygyno.2020.12.004; PMCID=PMC10039450

Karnezis A.N., Chen S.Y.-T., Chow C., Yang W., Hendricks W.P.D., Ramos P., Briones N., Mes-Masson A.-M., Bosse T., Gilks C.B., Trent J.M., Weissman B.E., Huntsman D.G., Wang Y.-M.

Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines.

Gynecol. Oncol. 160:568-578(2021)