HMC3

HMC3/HMC3细胞系/HMC3细胞株/HMC3人脑小胶质细胞

Cell line name HMC3

Synonyms Human Microglia Clone 3; CHME-3; CHME3

Accession CVCL_II76

Resource Identification Initiative To cite this cell line use: HMC3 (RRID:CVCL_II76)

Comments Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03070; SV40 large T antigen.

Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).

Derived from site: In situ; Fetal brain; UBERON=UBERON_0006238.

Cell type: Microglial cell; CL=CL_0000129.

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Children:

CVCL_D9WB (Ubigene HMC3 CLEC3B KO)

Sex of cell Sex unspecified

Age at sampling 8-10FW

Category Transformed cell line

STR profile Source(s): ATCC=CRL-3304; CLS=300102

 

Markers:

Amelogenin X

CSF1PO 10,11

D2S1338 17,25

D3S1358 16,18

D5S818 11,12

D6S1043 11

D7S820 9,11

D8S1179 13,14

D12S391 16,21

D13S317 11

D16S539 12,13

D18S51 18

D19S433 15,15.2

D21S11 30,31.2

FGA 21,25

Penta D 10,14

Penta E 7,13

TH01 6

TPOX 8,9

vWA 17,19

 

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Publications

PubMed=7478261; DOI=10.1016/0304-3940(94)11792-H

Janabi N., Peudenier S., Heron B., Ng K.H., Tardieu M.

Establishment of human microglial cell lines after transfection of primary cultures of embryonic microglial cells with the SV40 large T antigen.

Neurosci. Lett. 195:105-108(1995)

 

PubMed=16371321; DOI=10.1007/BF03033980

Lindberg C., Hjorth E., Post C., Winblad B., Schultzberg M.

Cytokine production by a human microglial cell line: effects of beta-amyloid and alpha-melanocyte-stimulating hormone.

Neurotox. Res. 8:267-276(2005)

 

PubMed=20375612; DOI=10.1159/000235563

Li B., Bedard K., Sorce S., Hinz B., Dubois-Dauphin M., Krause K.-H.

NOX4 expression in human microglia leads to constitutive generation of reactive oxygen species and to constitutive IL-6 expression.

J. Innate Immun. 1:570-581(2009)

 

PubMed=30200996; DOI=10.1186/s12974-018-1288-0; PMCID=PMC6131758

Dello Russo C., Cappoli N., Coletta I., Mezzogori D., Paciello F., Pozzoli G., Navarra P., Battaglia A.

The human microglial HMC3 cell line: where do we stand? A systematic literature review.

J. Neuroinflammation 15:259.1-259.24(2018)