KGN

KGN/KGN细胞系/KGN细胞株/KGN人卵巢颗粒细胞

Cell line name KGN

Accession CVCL_0375

Resource Identification Initiative To cite this cell line use: KGN (RRID:CVCL_0375)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Population: Japanese.

Doubling time: 46.4 hours (PubMed=11145608).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.

PubMed=11145608; DOI=10.1210/endo.142.1.7862

Nishi Y., Yanase T., Mu Y.-M., Oba K., Ichino I., Saito M., Nomura M., Mukasa C., Okabe T., Goto K., Takayanagi R., Kashimura Y., Haji M., Nawata H.

Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor.

Endocrinology 142:437-445(2001)

 

PubMed=15541573; DOI=10.1016/j.mce.2004.04.018

Havelock J.C., Rainey W.E., Carr B.R.

Ovarian granulosa cell lines.

Mol. Cell. Endocrinol. 228:67-78(2004)

 

PubMed=18980698; DOI=10.1186/1471-2407-8-319; PMCID=PMC2584659

Imai M., Muraki M., Takamatsu K., Saito H., Seiki M., Takahashi Y.

Spontaneous transformation of human granulosa cell tumours into an aggressive phenotype: a metastasis model cell line.

BMC Cancer 8:319.1-319.10(2008)

 

PubMed=19956657; DOI=10.1371/journal.pone.0007988; PMCID=PMC2777318

Schrader K.A., Gorbatcheva B., Senz J., Heravi-Moussavi A., Melnyk N., Salamanca C.M., Maines-Bandiera S.L., Cooke S.L., Leung P.C.K., Brenton J.D., Gilks C.B., Monahan J.E., Huntsman D.G.

The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors.

PLoS ONE 4:E7988-E7988(2009)

 

PubMed=20098707; DOI=10.1371/journal.pone.0008789; PMCID=PMC2808356

Benayoun B.A., Caburet S., Dipietromaria A., Georges A., D'Haene B., Pandaranayaka P.J.E., L'Hote D., Todeschini A.-L., Krishnaswamy S., Fellous M., De Baere E., Veitia R.A.

Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G).

PLoS ONE 5:E8789-E8789(2010)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469

Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., MirT., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

A landscape of pharmacogenomic interactions in cancer.

Cell 166:740-754(2016)

 

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

 

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775

Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Pan-cancer proteomic map of 949 human cell lines.

Cancer Cell 40:835-849.e8(2022)