TT

T.T(TT)/T.T(TT)细胞系/T.T(TT)细胞株/T.T(TT)人甲状腺癌细胞

Cell line name TT

Synonyms MTC-TT

Accession CVCL_1774

Resource Identification Initiative To cite this cell line use: TT (RRID:CVCL_1774)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Population: Caucasian.

Doubling time: ~83 hours (ATCC=CRL-1803).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.

Cell type: Parafollicular cell; CL=CL_0000570.

Sequence variations

Mutation; HGNC; 9967; RET; Simple; p.Cys634Trp (c.1902C>G); ClinVar=VCV000013918; Zygosity=Heterozygous (PubMed=7736432; PubMed=30737244; Cosmic-CLP=930299; DepMap=ACH-001321).

Mutation; HGNC; 11602; TBX3; Simple; p.Trp197Ter (c.591G>A); Zygosity=Heterozygous (PubMed=30737244; Cosmic-CLP=930299; DepMap=ACH-001321).

PubMed=2519210

Kameya T., Kadoya K., Iguchi H.

Characterization and calcitonin secretion of a human well differentiated C-cell tumor cell line.

Hum. Cell 2:231-237(1989)

 

PubMed=1516062

Yoshimoto K., Iwahana H., Fukuda A., Sano T., Saito S., Itakura M.

Role of p53 mutations in endocrine tumorigenesis: mutation detection by polymerase chain reaction-single strand conformation polymorphism.

Cancer Res. 52:5061-5064(1992)

 

DOI=10.1016/B978-0-12-333530-2.50007-1

Carey T.E.

Head and neck tumor cell lines.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

 

PubMed=7736432; DOI=10.1016/0165-4608(94)00185-E

Cooley L.D., Elder F.F.B., Knuth A., Gagel R.F.

Cytogenetic characterization of three human and three rat medullary thyroid carcinoma cell lines.

Cancer Genet. Cytogenet. 80:138-149(1995)

 

PubMed=7864888; DOI=10.1006/bbrc.1995.1287

Carlomagno F., Salvatore D., Santoro M.M., de Franciscis V., Quadro L., Panariello L., Colantuoni V., Fusco A.

Point mutation of the RET proto-oncogene in the TT human medullary thyroid carcinoma cell line.

Biochem. Biophys. Res. Commun. 207:1022-1028(1995)

 

PubMed=9046062; DOI=10.14670/HH-12.283

Zabel M., Grzeszkowiak J.

Characterisation of thyroid medullary carcinoma TT cell line.

Histol. Histopathol. 12:283-289(1997)

 

PubMed=11751535; DOI=10.1093/clinchem/48.1.25

Zammatteo N., Lockman L., Brasseur F., De Plaen E., Lurquin C., Lobert P.-E., Hamels S., Boon T., Remacle J.

DNA microarray to monitor the expression of MAGE-A genes.

Clin. Chem. 48:25-34(2002)

 

PubMed=19897677; DOI=10.1210/jc.2009-1485; PMCID=PMC2805480

Zhu W., Hai T., Ye L., Cote G.J.

Medullary thyroid carcinoma cell lines contain a self-renewing CD133+ population that is dependent on Ret proto-oncogene activity.

J. Clin. Endocrinol. Metab. 95:439-444(2010)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)