TPC-1

tpc-1/tpc-1细胞系/tpc-1细胞株/tpc-1人甲状腺乳头状细胞

Cell line name TPC-1

Synonyms TPC1

Accession CVCL_6298

Resource Identification Initiative To cite this cell line use: TPC-1 (RRID:CVCL_6298)

Comments Population: Japanese.

Omics: Mitochondrial genome sequenced.

Omics: Transcriptome analysis by microarray.

Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.

Sequence variations

Gene fusion; HGNC; 18782; CCDC6 + HGNC; 9967; RET; Name(s)=CCDC6-RET, RET/PTC1 (PubMed=7491517; PubMed=30737244).

Mutation; HGNC; 1787; CDKN2A; Simple; p.Ala68fs (c.204_208delGGAGC); Zygosity=Homozygous (PubMed=30737244).

Mutation; HGNC; 11355; STAG2; Simple; p.Gln1089Ter (c.3265C>T); Zygosity=Heterozygous (PubMed=30737244).

Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).

Disease Thyroid gland papillary carcinoma (NCIt: C4035)

Differentiated thyroid carcinoma (ORDO: Orphanet_146)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

PubMed=11439348; DOI=10.1038/sj.onc.1204531

Frasca F., Vigneri P., Vella V., Vigneri R., Wang J.Y.-J.

Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to hepatocyte growth factor.

Oncogene 20:3845-3856(2001)

 

PubMed=14522906

Frasca F., Vella V., Aloisi A., Mandarino A., Mazzon E., Vigneri R., Vigneri P.

p73 tumor-suppressor activity is impaired in human thyroid cancer.

Cancer Res. 63:5829-5837(2003)

 

PubMed=15980887; DOI=10.1038/labinvest.3700306

Nakamura N., Carney J.A., Jin L., Kajita S., Pallares J., Zhang H.-Y., Qian X., Sebo T.J., Erickson L.A., Lloyd R.V.

RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors.

Lab. Invest. 85:1065-1075(2005)

 

PubMed=16778181; DOI=10.1158/0008-5472.CAN-06-0171

Bonora E., Porcelli A.M., Gasparre G., Biondi A., Ghelli A., Carelli V., Baracca A., Tallini G., Martinuzzi A., Lenaz G., Rugolo M., Romeo G.

Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.

Cancer Res. 66:6087-6096(2006)

 

PubMed=17725429; DOI=10.1089/thy.2007.0097

Meireles A.M., Preto A., Rocha A.S., Rebocho A.P., Maximo V., Pereira-Castro I., Moreira S., Feijao T., Botelho T., Marques R., Trovisco V., Cirnes L., Alves C., Velho S., Soares P., Sobrinho-Simoes M.

Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.

Thyroid 17:707-715(2007)

 

PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026

van Staveren W.C.G., Weiss-Solis D.Y., Delys L., Duprez L., Andry G., Franc B., Thomas G., Libert F., Dumont J.-E., Detours V., Maenhaut C.

Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.

Cancer Res. 67:8113-8120(2007)

 

PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569

Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. 3rd, Smallridge R.C., Haugen B.R.

Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.

J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

 

PubMed=19087340; DOI=10.1186/1471-2407-8-371; PMCID=PMC2651892

Ribeiro F.R., Meireles A.M., Rocha A.S., Teixeira M.R.

Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples.

BMC Cancer 8:371.1-371.11(2008)

 

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662

Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.

Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.

Clin. Cancer Res. 17:7248-7264(2011)

 

PubMed=22087789; DOI=10.1186/1755-8166-4-26; PMCID=PMC3248874

Maric I., Viaggi S., Caria P., Frau D.V., Degan P., Vanni R.

Centrosomal and mitotic abnormalities in cell lines derived from papillary thyroid cancer harboring specific gene alterations.

Mol. Cytogenet. 4:26.1-26.8(2011)