Raji

Raji/Raji细胞系/Raji细胞株/Raji人EBV伯基特淋巴瘤

Cell line name Raji

Synonyms RAJI; P1-Raji; GM04671

Accession CVCL_0511

Resource Identification Initiative To cite this cell line use: Raji (RRID:CVCL_0511)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: ENCODE project common cell types; tier 3.

Part of: LL-100 blood cancer cell line panel.

Part of: MD Anderson Cell Lines Project.

Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).

Population: African; Nigerian.

Characteristics: Genetically heterogeneous, consists of 2 subclones (PubMed=27566572).

Virology: Contains 50-60 integrated copies of the EBV genome. One copy is integrated in intron 1 of the BACH2 gene (PubMed=14982850).

Doubling time: 23.2 hours (PubMed=8847894); ~24-36 hours (DSMZ=ACC-319); ~20 hours (BEI_Resources=ARP-9944).

Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526; Sanger).

Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: H3K27ac ChIP-seq epigenome analysis.

Omics: H3K4me3 ChIP-seq epigenome analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Omics: Virome analysis using RNAseq.

Misspelling: BAJI; Cosmic=998718.

Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.

Cell type: B-cell; CL=CL_0000236.

PubMed=6419122; DOI=10.1038/306760a0

Rabbitts T.H., Hamlyn P.H., Baer R.

Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma.

Nature 306:760-765(1983)

 

PubMed=6600440; DOI=10.1007/BF02617996

Uittenbogaart C.H., Cantor Y., Fahey J.L.

Growth of human malignant lymphoid cell lines in serum-free medium.

In Vitro 19:67-72(1983)

 

PubMed=6231253; DOI=10.1002/ijc.2910330407

Ehlin-Henriksson B., Klein G.

Distinction between Burkitt lymphoma subgroups by monoclonal antibodies: relationships between antigen expression and type of chromosomal translocation.

Int. J. Cancer 33:459-463(1984)

 

PubMed=6500159; DOI=10.1159/000163283

Gershwin M.E., Lentz D., Owens R.B.

Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.

Exp. Cell Biol. 52:361-370(1984)

 

PubMed=6547209; DOI=10.1038/309592a0

Rabbitts T.H., Forster A., Hamlyn P.H., Baer R.

Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma.

Nature 309:592-597(1984)

 

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720

Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.

Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.

Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

 

PubMed=6592381; DOI=10.1093/jnci/73.4.841

Favrot M.-C., Philip I., Philip T., Portoukalian J., Dore J.-F., Lenoir G.M.

Distinct reactivity of Burkitt's lymphoma cell lines with eight monoclonal antibodies correlated with the ethnic origin.

J. Natl. Cancer Inst. 73:841-847(1984)

 

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0

Drexler H.G., Gaedicke G., Minowada J.

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.

Leuk. Res. 9:209-229(1985)

 

PubMed=2998993

Steel C.M., Morten J.E.N., Foster E.

The cytogenetics of human B lymphoid malignancy: studies in Burkitt's lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines.

IARC Sci. Publ. 60:265-292(1985)

 

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1

Drexler H.G., Gaedicke G., Minowada J.

Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).

Leuk. Res. 9:549-559(1985)

 

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x

Drexler H.G., Gaedicke G., Minowada J.

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Leuk. Res. 9:537-548(1985)

 

PubMed=3905596

Favrot M.-C., Philip I., Philip T., Cabrillat H., Pinatel C., Dore J.-F., Lenoir G.M.

Immunophenotypic classification of 28 Burkitt cell lines with monoclonal antibodies and reagent selection for bone-marrow purging.

IARC Sci. Publ. 60:447-452(1985)

 

PubMed=3080238

Sieverts H., Alabaster O., Goldschmidts W., Magrath I.T.

Expression of surface antigens during the cell cycle in different growth phases of American and African Burkitt's lymphoma cell lines.

Cancer Res. 46:1182-1188(1986)

 

PubMed=3518877; DOI=10.3109/07357908609038260

Fogh J.

Human tumor lines for cancer research.

Cancer Invest. 4:157-184(1986)

 

PubMed=3026973; DOI=10.1002/ijc.2910390215

Ehlin-Henriksson B., Manneborg-Sandlund A., Klein G.

Expression of B-cell-specific markers in different Burkitt lymphoma subgroups.

Int. J. Cancer 39:211-218(1987)