LLC

LLC/LLC细胞系/LLC细胞株/LLC小鼠肺癌细胞

Cell line name    LL/2 (LLC1)
Synonyms    LL/2 (LLc1); LL/2(LLc1); LL/2; LL2; LLC1; LLC; Lewis lung carcinoma line 1; Lewis lung carcinoma; Lewis Lung Cancer; Lewis-Lung; Lewis Lung
Accession    CVCL_4358
Resource Identification Initiative    To cite this cell line use: LL/2 (LLC1) (RRID:CVCL_4358)
Comments    Doubling time: 21 hours (CLS=400263).
Omics: HLA class I peptidome analysis by proteomics.
Omics: Transcriptome analysis by microarray.
Caution: Could be identical to 3LL (Cellosaurus=CVCL_5653).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Disease    Malignant tumors of the mouse pulmonary system (NCIt: C21769)
Species of origin    Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy    Children:
CVCL_E1LR (HyCyte LL/2 (LLC1) KO-mIrf7)    CVCL_D6BW (HyCyte LL/2 (LLC1) KO-mKeap1)    CVCL_D6BX (HyCyte LL/2 (LLC1) KO-mMdm4)
CVCL_D6BY (HyCyte LL/2 (LLC1) KO-mMif)    CVCL_E1LS (HyCyte LL/2 (LLC1) KO-mSting1)    CVCL_RA22 (LL/2-eGFP-Puro)
CVCL_RA23 (LL/2-Fluc-Neo/eGFP-Puro)    CVCL_RA24 (LL/2-Fluc-Puro)    CVCL_RA25 (LL/2-iRFP-Puro)
CVCL_5J40 (LL/2-luc-M38)    CVCL_A4CM (LL/2-Luc2)    CVCL_RA26 (LL/2-mNIS (monoclonal))
CVCL_RA27 (LL/2-mNIS-Neo/eGFP-Puro)    CVCL_RA28 (LL/2-mNIS-Neo/Fluc-Puro)    CVCL_RA29 (LL/2-mNIS-Puro)
CVCL_5J02 (LL/2-Red-FLuc)    CVCL_H949 (LLAK)    CVCL_H948 (LLTC)
CVCL_E0X9 (Ubigene LLC Keap1 KO)    CVCL_E0XA (Ubigene LLC Nadk2 KO)
Category    Cancer cell line
STR profile    Source(s): PubMed=31220119; Ubigene=YC-C018

Markers:
Mouse STR 1-1    15,17,18
Mouse STR 1-2    18,19,20
Mouse STR 2-1    15,16
Mouse STR 3-2    13,14
Mouse STR 4-2    20.3,21.3,23.3 (PubMed=31220119)
21.3,23.3 (Ubigene=YC-C018)
Mouse STR 5-5    16,17,18 (PubMed=31220119)
16,17 (Ubigene=YC-C018)
Mouse STR 6-4    17,18 (PubMed=31220119)
18 (Ubigene=YC-C018)
Mouse STR 6-7    14,15,16 (PubMed=31220119)
15 (Ubigene=YC-C018)
Mouse STR 7-1    26.2,27.2,28.2
Mouse STR 8-1    16
Mouse STR 11-2    13.3,14.3,15.3,16
Mouse STR 12-1    17
Mouse STR 13-1    17,18
Mouse STR 15-3    22.3,24.3 (PubMed=31220119)
24.3,25.3 (Ubigene=YC-C018)
Mouse STR 17-2    14,15,16
Mouse STR 18-3    15,16
Mouse STR 19-2    13
Mouse STR X-1    24,26,28 (PubMed=31220119)
25,25.3 (Ubigene=YC-C018)

Run an STR similarity search on this cell line
Publications    
PubMed=7226139; DOI=10.1016/0304-3835(80)90130-5
Bertram J.S., Janik P.
Establishment of a cloned line of Lewis lung carcinoma cells adapted to cell culture.
Cancer Lett. 11:63-73(1980)

DOI=10.4051/ibc.2010.2.4.0014
Yoshino K., Saijo K., Noro C., Nakamura Y.
Development of a simple method to determine the mouse strain from which cultured cell lines originated.
Interdisciplinary Bio Central 2:1-9(2010)

PubMed=28599420; DOI=10.3892/ol.2017.5877; PMCID=PMC5453008
Stankevicius V., Kuodyte K., Schveigert D., Bulotiene D., Paulauskas T., Daniunaite K., Suziedelis K.
Gene and miRNA expression profiles of mouse Lewis lung carcinoma LLC1 cells following single or fractionated dose irradiation.
Oncol. Lett. 13:4190-4200(2017)

PubMed=30084848; DOI=10.1038/sdata.2018.157; PMCID=PMC6080492
Schuster H., Shao W.-G., Weiss T., Pedrioli P.G.A., Roth P., Weller M., Campbell D.S., Deutsch E.W., Moritz R.L., Planz O., Rammensee H.-G., Aebersold R., Caron E.
A tissue-based draft map of the murine MHC class I immunopeptidome.
Sci. Data 5:180157-180157(2018)

PubMed=31220119; DOI=10.1371/journal.pone.0218412; PMCID=PMC6586308
Almeida J.L., Dakic A., Kindig K., Kone M., Letham D.L.D., Langdon S., Peat R., Holding-Pillai J., Hall E.M., Ladd M., Shaffer M.D., Berg H., Li J.-L., Wigger G., Lund S., Steffen C.R., Fransway B.B., Geraghty B., Natoli M., Bauer B.A., Gollin S.M., Lewis D.W., Reid Y.A.
Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.
PLoS ONE 14:E0218412-E0218412(2019)