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T25
RGC-5/RGC-5细胞系/RGC-5细胞株/RGC-5小鼠视网膜神经节细胞株
Cell line name RGC-5
Synonyms RGC5
Accession CVCL_4059
Resource Identification Initiative To cite this cell line use: RGC-5 (RRID:CVCL_4059)
Comments Group: Patented cell line.
Problematic cell line: Misidentified. Originally thought to be of rat origin but found to be from mouse (PubMed=19443730; PubMed=24664692). Is probably identical to 661W (PubMed=23975727; PubMed=24021353). But the originator of the 661W cell is partially contesting this claim (PubMed=24472671).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00472.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-6600.
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen (Note=Under the control of the IRBP promoter).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Eye, retina; UBERON=UBERON_0000966.
Cell type: Retinal cone cell; CL=CL_0000573.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6N transgenic.
Hierarchy Parent: CVCL_6240 (661W)
Sex of cell Male
Category Transformed cell line
PubMed=11165366; DOI=10.1016/S0169-328X(00)00224-2
Krishnamoorthy R.R., Agarwal P., Prasanna G., Vopat K., Lambert W.S., Sheedlo H.J., Pang I.-H., Shade D.L., Wordinger R.J., Yorio T., Clark A.F., Agarwal N.
Characterization of a transformed rat retinal ganglion cell line.
Brain Res. Mol. Brain Res. 86:1-12(2001)
Patent=US7303915
Levin L.A.
In vitro-differentiated retinal ganglion cells and method for producing same.
Patent number US7303915, 04-Dec-2007
PubMed=19443730; DOI=10.1167/iovs.09-3484
Van Bergen N.J., Wood J.P.M., Chidlow G., Trounce I.A., Casson R.J., Ju W.-K., Weinreb R.N., Crowston J.G.
Recharacterization of the RGC-5 retinal ganglion cell line.
Invest. Ophthalmol. Vis. Sci. 50:4267-4272(2009)
PubMed=23975727; DOI=10.1167/iovs.13-12085
Krishnamoorthy R.R., Clark A.F., Daudt D., Vishwanatha J.K., Yorio T.
A forensic path to RGC-5 cell line identification: lessons learned.
Invest. Ophthalmol. Vis. Sci. 54:5712-5719(2013)
PubMed=24021353; DOI=10.1016/j.exer.2013.08.002
Clark A.F., Tamm E.R., Al-Ubaidi M.R., Hollyfield J.G.
On the use of immortalized ocular cell lines in vision research: the unfortunate story of RGC-5.
Exp. Eye Res. 116:433-433(2013)
PubMed=24472671; DOI=10.1016/j.exer.2013.10.012; PMCID=PMC3906592
Al-Ubaidi M.R.
RGC-5: are they really 661W? The saga continues.
Exp. Eye Res. 119:115-115(2014)
PubMed=24664692; DOI=10.1007/978-1-4614-3209-8_19
Sippl C., Tamm E.R.
What is the nature of the RGC-5 cell line?
Adv. Exp. Med. Biol. 801:145-154(2014)
PubMed=29203899; DOI=10.1038/s41598-017-17241-0; PMCID=PMC5715133
Sayyad Z., Sirohi K., Radha V., Swarup G.
661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively.
Sci. Rep. 7:16855-16855(2017)
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文献和实验*发表【中文论文】请标注：由上海酶研生物科技有限公司提供；
*发表【英文论文】请标注：From Shanghai EK-Bioscience Biotechnology Co., Ltd.
白细胞介素 IL-5 IL-5主要产生细胞：活化T细胞(Th2)、嗜酸粒细胞(同源二聚体) IL-5氨基酸数目：115 IL-5分子质量(kDa)：35-60 IL-5受体：CDl25 IL-5主要生物学活性：诱导小鼠B细胞分化为抗体分泌细胞、IgA合成；协同11-2促进CTL分化；促进人嗜酸粒细胞激活、增殖、分化和趋化
大鼠巨噬细胞炎性蛋白-5(MIP-5)ELISA试剂盒 说明书
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 大鼠巨噬细胞炎性蛋白 -5(MIP-5)ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗大鼠 MIP-5 单抗包被于酶标板上，标准品和样品中的 MIP-5 与单抗结合，加入生物素化的抗大鼠 MIP-5 ，形成免疫复合
Sci Adv：蒋若天 / 温祥毅揭示钾离子通道参与健康和衰老视网膜视觉信号调控新机制
视网膜神经节细胞（Retinal ganglion cell, RGC）不仅接收上级神经元的信号，还在信号进入大脑前，通过神经环路及离子通道等对视觉信息进行线性或非线性计算。尽管多种机制可以调节 RGC 的兴奋性及动作电位放电模式，但 RGC 兴奋性变化如何调控初级视觉环路，特别是如何对非线性视觉信号处理的分子机制和原理尚不完全清晰。 在光感受器细胞和双极细胞以及双极细胞和 RGC 的突触之间，神经元活动介导的胞外酸化（extracellular acidification）可将突触
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