Min6细胞

Min6/Min6细胞系/Min6细胞株/Min6小鼠胰岛β细胞株

Cell line name MIN6

Synonyms Min6; MIN-6; Mouse INsulinoma 6

Accession CVCL_0431

Resource Identification Initiative To cite this cell line use: MIN6 (RRID:CVCL_0431)

Comments Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).

Omics: Cell surface proteome.

Omics: Endoplasmic reticulum proteome analysis.

Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.

Cell type: Pancreatic beta cell; CL=CL_0000169.

Disease Mouse insulinoma (NCIt: C34053)

Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)

Breed/subspecies: C57BL/6 IT6 transgenic.

Hierarchy Children:

CVCL_A7QH (MIN6 rho0) CVCL_A8QH (MIN6-cl4) CVCL_4372 (MIN6-m14)

CVCL_4371 (MIN6-m9) CVCL_D686 (MIN6N8)

Sex of cell Sex unspecified

Age at sampling 13W

Category Transformed cell line

Publications

PubMed=2163307; DOI=10.1210/endo-127-1-126

Miyazaki J.-i., Araki K., Yamato E., Ikegami H., Asano T., Shibasaki Y., Oka Y., Yamamura K.-i.

Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms.

Endocrinology 127:126-132(1990)

 

PubMed=8697299

Poitout V., Olson L.K., Robertson R.P.

Insulin-secreting cell lines: classification, characteristics and potential applications.

Diabetes Metab. 22:7-14(1996)

 

PubMed=8824267; DOI=10.1074/jbc.271.42.26194

Soejima A., Inoue K., Takai D., Kaneko M., Ishihara H., Oka Y., Hayashi J.-i.

Mitochondrial DNA is required for regulation of glucose-stimulated insulin secretion in a mouse pancreatic beta cell line, MIN6.

J. Biol. Chem. 271:26194-26199(1996)

 

PubMed=18845907; DOI=10.1507/endocrj.K08E-172

Nakashima K., Kanda Y., Hirokawa Y., Kawasaki F., Matsuki M., Kaku K.

MIN6 is not a pure beta cell line but a mixed cell line with other pancreatic endocrine hormones.

Endocr. J. 56:45-53(2009)

 

PubMed=22538498; DOI=10.1159/000338793

Grozinsky-Glasberg S., Shimon I., Rubinfeld H.

The role of cell lines in the study of neuroendocrine tumors.

Neuroendocrinology 96:173-187(2012)

 

PubMed=22808281; DOI=10.1371/journal.pone.0040868; PMCID=PMC3396628

Cheng K., Delghingaro-Augusto V., Nolan C.J., Turner N., Hallahan N., Andrikopoulos S., Gunton J.E.

High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation.

PLoS ONE 7:E40868-E40868(2012)

 

PubMed=23560115; DOI=10.1371/journal.pone.0061211; PMCID=PMC3616144

Yamato E., Tashiro F., Miyazaki J.-i.

Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic beta cell line MIN6.

PLoS ONE 8:E61211-E61211(2013)

 

PubMed=25546123; DOI=10.1002/pmic.201400345; PMCID=PMC4489703

Lee J.-S., Wu Y.-N., Schnepp P., Fang J.-Y., Zhang X.-B., Karnovsky A., Woods J., Stemmer P.M., Liu M., Zhang K.-Z., Chen X.-Q.

Proteomics analysis of rough endoplasmic reticulum in pancreatic beta cells.

Proteomics 15:1508-1511(2015)

 

PubMed=25894527; DOI=10.1371/journal.pone.0121314; PMCID=PMC4404347

Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A.S., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.

A mass spectrometric-derived cell surface protein atlas.

PLoS ONE 10:E0121314-E0121314(2015)