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T25
DT40、DT40细胞、DT40DT40（鸡淋巴瘤细胞)
Cell line name DT40
Synonyms DT-40; DT 40; DT40B; LSCC-DT40
Accession CVCL_0249
Resource Identification Initiative To cite this cell line use: DT40 (RRID:CVCL_0249)
Comments Group: Bird cell line.
Doubling time: ~48 hours (DSMZ=ACC-636); ~1 day (Note=Lot 02272006) (JCRB=JCRB9130).
Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
Omics: Deep proteome analysis.
Omics: Genome sequenced.
Cell type: B-cell; CL=CL_0000236.
Disease Chicken bursal lymphoma (NCIt: C134556)
Species of origin Gallus gallus (Chicken) (NCBI Taxonomy: 9031)
Breed/subspecies: Hy-Line SC.
Hierarchy Children:
Sex of cell Female
Age at sampling 1D
Category Cancer cell line
Publications
PubMed=2998040; DOI=10.1016/0042-6822(85)90312-5
Baba T.W., Giroir B.P., Humphries E.H.
Cell lines derived from avian lymphomas exhibit two distinct phenotypes.
Virology 144:139-151(1985)
PubMed=18766641; DOI=10.1080/03079458708436402
Nazerian K.
An updated list of avian cell lines and transplantable tumours.
Avian Pathol. 16:527-544(1987)
PubMed=11226459; DOI=10.1016/S0022-1759(00)00333-1
Winding P., Berchtold M.W.
The chicken B cell line DT40: a novel tool for gene disruption experiments.
J. Immunol. Methods 249:1-16(2001)
PubMed=17675859; DOI=10.1159/000103179
Bachl J., Caldwell R.B., Buerstedde J.-M.
Biotechnology and the chicken B cell line DT40.
Cytogenet. Genome Res. 117:189-194(2007)
PubMed=19181659; DOI=10.1074/mcp.M800394-MCP200; PMCID=PMC2690488
Hall S.L., Hester S., Griffin J.L., Lilley K.S., Jackson A.P.
The organelle proteome of the DT40 lymphocyte cell line.
Mol. Cell. Proteomics 8:1295-1305(2009)
PubMed=25227228; DOI=10.1534/g3.114.013482; PMCID=PMC4232548
Molnar J., Poti A., Pipek O., Krzystanek M., Kanu N., Swanton C., Tusnady G.E., Szallasi Z., Csabai I., Szuts D.
The genome of the chicken DT40 bursal lymphoma cell line.
G3 (Bethesda) 4:2231-2240(2014)
PubMed=26217713; DOI=10.1016/j.dib.2014.12.006; PMCID=PMC4509924
Rees J.S., Lilley K.S., Jackson A.P.
The chicken B-cell line DT40 proteome, beadome and interactomes.
Data Brief 3:29-33(2015)
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文献和实验*发表【中文论文】请标注：由上海酶研生物科技有限公司提供；
*发表【英文论文】请标注：From Shanghai EK-Bioscience Biotechnology Co., Ltd.
Establishment of the DNA Repair-Defective Mutants in DT40 Cells
The chicken B cell line DT40 has been widely used as a model system for reverse genetics studies in higher eukaryotes, because of its advantages including efficient gene targeting and ease of chromosome manipulation. Although the genetic
Characterizing Somatic Hypermutation and Gene Conversion in the Chicken DT40 Cell System
of activation-induced cytidine deaminase, an enzyme that deaminates cytosine in the context of single-stranded DNA. The chicken DT40 B-cell line is an important model system for exploring the mechanisms of SHM and GCV, as both processes occur constitutively
Measurement of Diversification in the Immunoglobulin Light Chain Gene of DT40 Cells
The immunoglobulin loci of the genetically tractable chicken B cell line DT40 provide a unique opportunity to study the cellular response to endogenously generated DNA damage in a chromosomal context. Abasic sites generated by the concerted
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