MCF10A细胞

MCF 10A/MCF 10A细胞系/MCF 10A细胞株/MCF 10A人正常乳腺上皮细胞

Cell line name MCF-10A

Synonyms MCF 10A; MCF.10A; MCF10A; MCF10-A; MCF10a; MCF-10 Attached; Michigan Cancer Foundation-10A

Accession CVCL_0598

Resource Identification Initiative To cite this cell line use: MCF-10A (RRID:CVCL_0598)

Comments Group: Patented cell line.

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: JWGray breast cancer cell line panel.

Part of: ICBP43 breast cancer cell line panel.

Part of: MD Anderson Cell Lines Project.

Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10317.

Doubling time: 97.4 hours (PubMed=24389870); 20 hours (PubMed=34238275); 26.74 hours (JWGray panel).

Microsatellite instability: Stable (MSS) (PubMed=12661003).

Omics: Array-based CGH.

Omics: CNV analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Exosome proteome analysis.

Omics: Glycoproteome analysis by proteomics.

Omics: H2BK120ub ChIP-seq epigenome analysis.

Omics: H3K23ac ChIP-seq epigenome analysis.

Omics: H3K27ac ChIP-seq epigenome analysis.

Omics: H3K27me3 ChIP-seq epigenome analysis.

Omics: H3K36me3 ChIP-seq epigenome analysis.

Omics: H3K4me1 ChIP-seq epigenome analysis.

Omics: H3K4me3 ChIP-seq epigenome analysis.

Omics: H3K79me2 ChIP-seq epigenome analysis.

Omics: H3K9ac ChIP-seq epigenome analysis.

Omics: H3K9me3 ChIP-seq epigenome analysis.

Omics: H4K8ac ChIP-seq epigenome analysis.

Omics: Metabolome analysis.

Omics: N-glycan profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.

PubMed=12661003; DOI=10.1002/gcc.10196

Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U., Santibanez-Koref M.F., Schlag P.M., Scherneck S.

Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.

Genes Chromosomes Cancer 37:29-35(2003)

 

PubMed=15153330; DOI=10.1593/neo.3292; PMCID=PMC1502105

Watts G.S., Oshiro M.M., Junk D.J., Wozniak R.J., Watterson S.J., Domann F.E., Futscher B.W.

The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells.

Neoplasia 6:187-194(2004)

 

PubMed=15375546; DOI=10.3892/ijo.25.4.961

Peng X.-J., Yun D.-R., Christov K.

Breast cancer progression in MCF10A series of cell lines is associated with alterations in retinoic acid and retinoid X receptors and with differential response to retinoids.

Int. J. Oncol. 25:961-971(2004)

 

PubMed=16271952; DOI=10.1016/j.cancergencyto.2005.04.019

Cowell J.K., LaDuca J.R., Rossi M.R., Burkhardt T., Nowak N.J., Matsui S.-i.

Molecular characterization of the t(3;9) associated with immortalization in the MCF10A cell line.

Cancer Genet. Cytogenet. 163:23-29(2005)

 

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521

Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T., Clark L., Bayani N., Coppe J.-P., Tong F., Speed T., Spellman P.T., DeVries S., Lapuk A., Wang N.J., Kuo W.-L., Stilwell J.L., Pinkel D., Albertson D.G., Waldman F.M., McCormick F., Dickson R.B., Johnson M.D., Lippman M.E., Ethier S.P., Gazdar A.F., Gray J.W.

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

Cancer Cell 10:515-527(2006)

 

PubMed=17334996; DOI=10.1002/gcc.20438

Jonsson G., Staaf J., Olsson E., Heidenblad M., Vallon-Christersson J., Osoegawa K., de Jong P.J., Oredsson S.M., Ringner M., Hoglund M., Borg A.

High-resolution genomic profiles of breast cancer cell lines assessed by tiling BAC array comparative genomic hybridization.

Genes Chromosomes Cancer 46:543-558(2007)

 

PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084

Kao J., Salari K., Bocanegra M., Choi Y.-L., Girard L., Gandhi J., Kwei K.A., Hernandez-Boussard T., Wang P., Gazdar A.F., Minna J.D., Pollack J.R.

Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.

PLoS ONE 4:E6146-E6146(2009)

 

PubMed=20169162; DOI=10.1371/journal.pone.0009201; PMCID=PMC2821407

Kadota M., Yang H.H., Gomez B.P., Sato M., Clifford R.J., Meerzaman D., Dunn B.K., Wakefield L.M., Lee M.P.

Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines.

PLoS ONE 5:E9201-E9201(2010)

 

PubMed=22414580; DOI=10.1158/0008-5472.CAN-11-3711

Geiger T., Madden S.F., Gallagher W.M., Cox J., Mann M.

Proteomic portrait of human breast cancer progression identifies novel prognostic markers.

Cancer Res. 72:2428-2439(2012)

 

PubMed=24009699; DOI=10.1371/journal.pone.0072704; PMCID=PMC3751845

Liu X., Nie H., Zhang Y.-B., Yao Y.-F., Maitikabili A., Qu Y.-P., Shi S.-L., Chen C.-Y., Li Y.

Cell surface-specific N-glycan profiling in breast cancer.

PLoS ONE 8:E72704-E72704(2013)

 

PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020; PMCID=PMC3931310

Timmerman L.A., Holton T., Yuneva M., Louie R.J., Padro M., Daemen A., Hu M., Chan D.A., Ethier S.P., van 't Veer L.J., Polyak K., McCormick F., Gray J.W.

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.

Cancer Cell 24:450-465(2013)