Calu-3细胞

【Calu-3】Calu-3细胞/Calu-3细胞/Calu-3人肺腺癌细胞Cell line name Calu-3

Synonyms CaLu-3; CALU-3; Calu 3; Calu3; CALU3

Accession CVCL_0609

Resource Identification Initiative To cite this cell line use: Calu-3 (RRID:CVCL_0609)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: KuDOS 95 cell line panel.

Part of: MD Anderson Cell Lines Project.

From: Memorial Sloan Kettering Cancer Center; New York; USA.

Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-533.

Population: Caucasian.

Virology: Susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=34339474).

Doubling time: 35 hours (Note=In RPMI 1640 + 10% FBS), 45 hours (Note=In ACL-3), 37 hours (Note=In ACL-3+BSA) (PubMed=3940644); 40.1 hours (PubMed=29681454); ~84 hours (PubMed=34339474).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Array-based CGH.

Omics: Cell surface proteome.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Misspelling: CALV3; Cosmic=1434969.

Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.

PubMed=3518877; DOI=10.3109/07357908609038260

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Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl-secretion.

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Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery.

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PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040

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Established cell lines used in cystic fibrosis research.

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Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification.

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PubMed=18083107; DOI=10.1016/j.cell.2007.11.025

Rikova K., Guo A.-L., Zeng Q.-F., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y.-R., Tan Z.-P., Stokes M.P., Sullivan L., Mitchell J., Wetzel R., MacNeill J., Ren J.-M., Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D.-Q., Zhou X.-M., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.

Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.

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The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer.

Hum. Mol. Genet. 18:1343-1352(2009)

 

PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846

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A gene-alteration profile of human lung cancer cell lines.

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Yoshikawa T., Hill T.E., Yoshikawa N., Popov V.L., Galindo C.L., Garner H.R., Peters C.J., Tseng C.-T.

Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection.

PLoS ONE 5:E8729-E8729(2010)