表皮生长因子 人|EGF *Sigma货号：E9644-.2

应用
该产品用作促分裂原，在各种细胞系中引发细胞开始有丝分裂
在组织培养中，EGF可用于减少或消除对血清的需求，并可与其他培养基添加剂和激素一起使用
[1][2][3][4][5]

生化/生理作用

Epidermal growth factor (EGF) is a small mitogenic peptide found in a large number of tissues and body fluids in many mammalian species. EGF is a member of the growth factor family, characterized by the formation of six conserved cysteine motifs with three disulfide bonds. EGF has a mitogenic effect on various epidermal and epithelial cells, including fibroblasts, glial cells, vascular and corneal endothelial cells, bovine granulosa cells, HeLa cells, SV40-3T3 cells, and mammary epithelial cells Cellular functions affected by EGF: mitosis, ion flux, glucose transport, glycolysis, nucleic acid and protein synthesis, survival, growth, proliferation, and differentiation The biological effects of EGF: inhibition of gastric acid secretion, fetal growth and development, and neural regulation of the central nervous system Pathways affected by EGF: EGFR signaling pathway, MAPK cascade reaction pathway, PIP, Ca+2 signaling pathway