地塞米松 *Sigma货号：D1756-500MG/D175

一般描述

Dexamethasone is a potent glucocorticoid with minimal to no mineralocorticoid activity. Dexamethasone exhibits pleiotropic effects on multiple signaling pathways,[1] some of its functions include, inhibition of neutrophil migration and reduction of lymphocyte colony proliferation. Research findings show, dexamethasone might prevent high-altitude pulmonary edema by decreasing pulmonary artery pressure. 应用
地塞米松已用于：
诱导脂肪干细胞分化为成骨组织的培养基[2]
用作脂肪细胞分化培养基的组分[3]
体外刺激原代正常人支气管上皮细胞(NHBE)和气道平滑肌(ASM)

生化/生理作用

现已确知地塞米松对复发多发性骨髓瘤有效
[5]这种成分经证可减少与脑脊液和中枢神经系统(CNS)并发症（如听力损失）相关的炎症
[6] 糖皮质激素抗炎剂
调节T细胞生存、生长和分化
抑制一氧hua氮合酶活性的诱导