过氧化氢酶 来源于牛肝脏 *Sigma货号：E3289-10

一般描述

过氧化氢酶由位于人染色体11p13的基因编码
[1]哺乳动物过氧化氢酶是一种抗氧化酶，是氢过氧化物酶家族的成员
活性酶本质上是同四聚体
[2][3] Research Area: Cell Signaling Catalase from bovine liver is a tetramer consisting of 4 equal subunits each with a 60 kDa molecular weight. Each of these subunits contains iron bound to a protoheme IX group. The enzyme will also strongly bind to NADP, where NADP and the heme group are within 13.7 angstroms. 应用
来自牛肝的过氧化氢酶已被用作Gloxy成分，而后者是最流行的除氧系统之一
[4] 过氧化氢酶作为天然抗氧化剂，可用于研究活性氧物质对基因表达和凋亡的作用
它还被用于保护蛋白质、脂质和核酸免受氧化损伤
工业上，过氧化氢酶已被用于去除添加至牛奶和奶酪中以及纺织品漂白使用的过氧化氢，并用于检查其对DNA修复大肠杆菌突变体活力的阳性效应

生化/生理作用

过氧化氢酶可将太阳辐射能转化为活性氧 (ROS)
其参与组织过氧化物水平调节
[2]过氧化氢酶基因突变会导致原发性高血压 (EH) 发展
[5] Catalase, an antioxidant enzyme found in all aerobic organisms, catalyzes the degradation of hydrogen peroxide, a byproduct of metabolic processes, into less harmful water and oxygen. It can also react with alkylhydrogen peroxides, such as methylperoxide and ethylperoxide and the second H2O2 molecule can be replaced by methanol, ethanol, propanol, formate and nitrate as a hydrogen donor. Catalase enzyme uses either iron (Fe) or manganese (Mn) as cofactor, and are classified as Fe-CAT or Mn-CAT.