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- 详细信息
- 技术资料
- 标记物:
Unconjugated
- 适应物种:
Human;Rat
- 供应商:
武汉恩玑生命科技有限公司
- 宿主:
Rabbit
- 应用范围:
WB;IP
- 规格:
50uL/100uL
| 规格: | 50uL | 产品价格: | ¥1350.0 |
|---|---|---|---|
| 规格: | 100uL | 产品价格: | ¥2250.0 |
产品概述
产品性能
免疫原
产品应用
研究背景
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).
研究领域
Signal Transduction
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