- ￥1200 - 2150
- EnkiLife
- AMM03420
- 2025年11月18日
- WB;ChIP
- Mouse
- Human;Mouse
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- 详细信息
- 技术资料
- 标记物：
Unconjugated
- 适应物种：
Human;Mouse
- 供应商：
武汉恩玑生命科技有限公司
- 宿主：
Mouse
- 应用范围：
WB;ChIP
- 规格：
50uL/100uL
| 规格： | 50uL | 产品价格： | ￥1200.0 |
|---|---|---|---|
| 规格： | 100uL | 产品价格： | ￥2150.0 |
产品概述
产品性能
免疫原
产品应用
研究背景
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029).
研究领域
Epigenetics and Nuclear Signaling
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