- ￥1350 - 2250
- EnkiLife
- AMRe03997
- 2025年07月12日
- WB;FC
- Rabbit
- Human;Mouse;Rat
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- 详细信息
- 技术资料
- 标记物：
Unconjugated
- 适应物种：
Human;Mouse;Rat
- 供应商：
武汉恩玑生命科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB;FC
- 规格：
50uL/100uL
| 规格： | 50uL | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100uL | 产品价格： | ￥2250.0 |
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产品应用
研究背景
G protein-coupled inwardly rectifying potassium channels (KIR3.1 through KIR3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, KIR3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbγ subunits from G protein heterotrimers bind to and regulate KIR3 channel activity. Gb3- and Gb4-containing Gbγ dimers bind directly to cytoplasmic domains of KIR3 proteins and increase the K+ current while Gb5-containing Gbγ dimers inhibit KIR3 K+ current. KIR3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates KIR3 tyrosine residues, effectively inactivating the KIR3 channels.
研究领域
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