- ￥1350 - 2250
- EnkiLife
- AMRe01580
- 2025年07月14日
- WB;IHC;IP
- Rabbit
- Human;Mouse
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- 详细信息
- 技术资料
- 标记物：
Unconjugated
- 适应物种：
Human;Mouse
- 供应商：
武汉恩玑生命科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB;IHC;IP
- 规格：
50uL/100uL
| 规格： | 50uL | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100uL | 产品价格： | ￥2250.0 |
产品概述
产品性能
免疫原
产品应用
研究背景
Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).
研究领域
Cell Biology
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