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- 2025年07月12日
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- 详细信息
- 技术资料
- 英文名：
IL-15RA&IL-15 Complex/IL-15 R alpha & IL-15 Fusion Protein/IL15RA&IL15
- 供应商：
武汉恩玑生命科技有限公司
- 规格：
10ug/50ug/500ug
| 规格： | 10ug | 产品价格： | ￥750.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2280.0 |
| 规格： | 500ug | 产品价格： | ￥11000.0 |
| 产品名称 |
Recombinant Human IL-15RA&IL-15 Complex (C-Fc) |
| 英文名称 |
IL-15RA&IL-15 Complex/IL-15 R alpha & IL-15 Fusion Protein/IL15RA&IL15 |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Interleukin-15 Receptor Alpha & Interleukin-15 Fusion Protein Complex is produced by our Mammalian expression system and the target gene encoding Ile31-Asp96&Asn49-Ser162 (Asn120Asp) is expressed with a human IgG1 Fc tag at the C-terminus. |
| Accession |
Q13261&P40933 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
34.4&12.8 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| IL-15 Receptor alpha & IL-15 Fusion Protein; IL15RA&IL15; IL15RA&IL15 Complex; Interleukin-15; IL-15; IL15 |
| 背景介绍 |
| IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each others activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs. The enhanced activity of the IL-15N72D:IL-15RαSu/Fc complex is likely the result of the increased binding activity of IL-15N72D to IL-15Rβγ c , optimized cytokine trans-presentation by the IL-15RαSu domain, the dimeric nature of the cytokine domain and its increased in vivo half-life compared to IL-15. These findings indicate that this IL-15 superagonist complex could serve as a superior immunostimulatory therapeutic agent. |
注意事项
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