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- PEH0768
- 2025年11月14日
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- 详细信息
- 技术资料
- 英文名：
Guanidinoacetate N-methyltransferase/GAMT
- 供应商：
武汉恩玑生命科技有限公司
- 规格：
10ug/50ug/500ug
| 规格： | 10ug | 产品价格： | ￥690.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2080.0 |
| 规格： | 500ug | 产品价格： | ￥10980.0 |
| 产品名称 |
Recombinant Human GAMT (N, C-6His) |
| 英文名称 |
Guanidinoacetate N-methyltransferase/GAMT |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Guanidinoacetate N-methyltransferase is produced by our E.coli expression system and the target gene encoding Met1-Gly236 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus. |
| Accession |
Q14353 |
| 表达宿主 |
E.coli |
| 种属 |
Human |
| 预测分子量 |
29.5 KDa |
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, pH 8.0. |
| 运输方式 |
The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
| 分子别名 |
| Guanidinoacetate N-methyltransferase; GAMT; PIG2; TP53I2 |
| 背景介绍 |
| GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids. |
注意事项
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