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- 2025年11月14日
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- 详细信息
- 技术资料
- 英文名：
CD161/Killer cell lectin-like receptor subfamily B member 1/KLRB1
- 供应商：
武汉恩玑生命科技有限公司
- 规格：
10ug/50ug/500ug
| 规格： | 10ug | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥1520.0 |
| 规格： | 500ug | 产品价格： | ￥12600.0 |
| 产品名称 |
Recombinant Human CD161 (N-Fc) |
| 英文名称 |
CD161/Killer cell lectin-like receptor subfamily B member 1/KLRB1 |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Killer cell lectin-like receptor subfamily B member 1 is produced by our Mammalian expression system and the target gene encoding Lys68-Ser225 is expressedwith a human IgG1 Fc tag at the N-terminus. |
| Accession |
Q12918 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
45 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| Killer cell lectin-like receptor subfamily B member 1;KLRB1;CLEC5B; NKRP1A;CD161;Natural killer cell surface protein P1A;NKR-P1A;HNKR-P1a;C-type lectin domain family 5 member B;KLRB1 |
| 背景介绍 |
| Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
注意事项
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