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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Latent TGF Beta-1&GARP Complex Protein
- 供应商：
武汉恩玑生命科技有限公司
- 规格：
10ug/50ug/500ug
| 规格： | 10ug | 产品价格： | ￥1080.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥3180.0 |
| 规格： | 500ug | 产品价格： | ￥15000.0 |
| 产品名称 |
Recombinant Human Latent TGF Beta-1&GARP Complex Protein (N-6His, C-3*Strep) |
| 英文名称 |
Latent TGF Beta-1&GARP Complex Protein |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Latent TGF Beta-1&GARP Complex Protein is produced by our Mammalian expressionsystem and the target gene encoding Leu30-Ser390&His20-Asn627 is expressed with a 6His tag at the N-terminusand, a 3*Strep tag at the C-terminus. |
| Accession |
P01137&Q14392 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
42.1&71.0 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, 5%Trehalose, 5% Mannitol, 0.05% Tween 80, pH 7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| TGF Beta-1&GARP |
| 背景介绍 |
| Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. Leucine Rich Repeat Containing 32 (LRRC32), also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T(regs). LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation. |
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文献和实验Strep/FLAG Tandem Affinity Purification (SF‐TAP) to Study Protein Interactions
Figure 19.20.1 The Strep/FLAG tandem affinity purification. (A ) N‐ and C‐terminal SF‐TAP tags (POI, protein of interest). (B ) Overview of both purification steps. (1) Purification by the tandem Strep‐tag II moiety: binding to Strep‐Tactin matrix
Experimental Applications: Human Acetylcholinesterase as a Model Nervous System Protein
, 5 ng in vitro-transcribed AChE mRNA directed the production of catalytically active recombinant human acetylcholinesterase (rHAChE), at levels of approx 10-fold above background oocyte levels (Table 6 ). Oocyte-produced rHAChE was sensitive to the AChE
Human Complement Components C4A and C4B Genetic Diversities: Complex Genotypes and Phenotypes
. Bristow, J., Tee, M.K., Gitelman, S.E., Mellon, S.H., and Miller, W.L. 1993. Tenascin‐X: A novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B. J. Cell. Biol. 122:265‐278
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