GRIK2抗体;GRIK2 Polyclonal Antib

Description Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. References 1.Biochemistry. 2010 Nov 2;49(43):9207-16. 2.Mol Pharmacol. 2009 May;75(5):1096-107. Specification Aliases:EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2 Entrez GeneID:2898 Swissprot:Q13002  clone:8A1F11 WB Predicted band size:102.5kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human GRIK2 (AA: extra 45-226) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application ELISA:1/10000