EIF2AK3抗体;EIF2AK3 Polyclonal A

Description The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. References 1. Autophagy. 2008 Apr 1;4(3):364-7. 2. J Biol Chem. 2008 Jun 20;283(25):17020-9. 3. Hum Mol Genet. 2008 Oct 15;17(20):3254-62. Specification Aliases:PEK; WRS; PERK; EIF2AK3 Entrez GeneID:9451 Swissprot:Q9NZJ5 clone:5G5 WB Predicted band size:125kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human EIF2AK3 expressed in E. Coli. Formulation:Ascitic fluid containing 0.03% sodium azide. Application ELISA:1/10000