MAPK7抗体;MAPK7 Polyclonal Antib

Description The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. References 1. Br J Cancer. 2011 Feb 15;104(4):664-72.2. PLoS One. 2009;4(5):e5565. Specification Aliases:BMK1; ERK4; ERK5; PRKM7 Entrez GeneID:5598 Swissprot:Q13164 clone:8H1D5 WB Predicted band size:88.4kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human MAPK7 (AA: 411-556) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide. Application IHC:1/200 - 1/1000 ELISA:1/10000