HLA-DRA抗体;HLA-DRA Polyclonal A

Description HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. References 1.Int J Immunogenet. 2014 Dec;41(6):508-11. 2.Am J Rhinol Allergy. 2012 Jan-Feb;26(1):12-7. Specification Aliases:MLRW; HLA-DRA1 Entrez GeneID:3122 Swissprot:P01903 clone:1C11A5 WB Predicted band size:28.6kDa Host/Isotype:Mouse IgG2b Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human HLA-DRA (AA: 26-254) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application WB:1/500 - 1/2000 ICC:1/100 - 1/500 FCM:1/200 - 1/400 ELISA:1/10000