HLA-C抗体;HLA-C Polyclonal Antib

Description HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency vi r us (HIV), and the severe acute respiratory syndrome coronavi r us (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavi r us SARS-CoV-2, which causes coronavi r us disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a vi r us across a population. References 1.J Dermatol Sci. 2020 Jul;99(1):23-29.2.Sci Rep. 2020 Jul 24;10(1):12424. Specification Aliases:MHC; HLAC; HLC-C; D6S204; PSORS1; HLA-JY3 Entrez GeneID:3107 Swissprot:P10321 clone:3C9E11 WB Predicted band size:40.6kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human, Mouse Immunogen:Purified recombinant fragment of human HLA-C (AA: 25-308) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application WB:1/500 - 1/2000 IHC:1/200 - 1/1000 ELISA:1/10000