ELANE抗体;ELANE Polyclonal Antib

Description Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. References 1.Pediatr Blood Cancer. 2015 Dec;62(12):2229-31. 2.Lung. 2014 Aug;192(4):595-9. Specification Aliases:GE; NE; HLE; HNE; ELA2; SCN1; PMN-E Entrez GeneID:1991 Swissprot:P08246 clone:6B6G6 WB Predicted band size:28.5kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human,Rat Immunogen:Purified recombinant fragment of human ELANE (AA: 140-267) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application WB:1/500 - 1/2000 FCM:1/200 - 1/400 ELISA:1/10000