CARD16抗体;CARD16 Polyclonal Ant

Description Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. Specification Aliases:COP; COP1; PSEUDO-ICE Swissprot:Q5EG05 WB Predicted band size:23 kDa Host/Isotype:Rabbit IgG Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Synthetic peptide of human CARD16 Formulation:pH7.4 PBS, 0.05% NaN3, 40% Glycerol Application WB:1/500-1/2000 IHC:1/40-1/200 ELISA:1/5000-1/10000