PSEN1抗体;PSEN1 Polyclonal Antib

Description Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. Specification Aliases:AD3; FAD; PS1; PS-1; S182; ACNINV3 Swissprot:P49768 WB Predicted band size:53 kDa Host/Isotype:Rabbit IgG Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human, Mouse Immunogen:Synthetic peptide of human PSEN1 Formulation:pH7.4 PBS, 0.05% NaN3, 40% Glycerol Application WB:1/1000-1/5000 IHC:1/50-1/200 ELISA:1/5000-1/10000