PFKFB3抗体;PFKFB3 Polyclonal Ant

Description The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. Specification Aliases:PFK2; IPFK2; iPFK-2 Swissprot:Q16875 WB Predicted band size:60 kDa Host/Isotype:Rabbit IgG Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human, Rat Immunogen:Synthetic peptide of human PFKFB3 Formulation:pH7.4 PBS, 0.05% NaN3, 40% Glycerol Application WB:1/500-1/2000 ELISA:1/5000-1/10000