HUWE1抗体;HUWE1 Polyclonal Antib

Description This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. Specification Aliases:MULE; Ib772; LASU1; UREB1; HECTH9; URE-B1; ARF-BP1; HSPC272 Swissprot:Q7Z6Z7 Host/Isotype:Rabbit IgG Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human, Mouse, Rat Immunogen:Synthetic peptide of human HUWE1 Formulation:pH7.4 PBS, 0.05% NaN3, 40% Glycerol Application IHC:1/10-1/50 ELISA:1/5000-1/10000