DDIT3抗体;DDIT3 Polyclonal Antib

Description This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. References 1. J Exp Clin Cancer Res. 2010 May 23;29:54.2. J Biol Chem. 2010 Jun 25;285(26):19710-9. Specification Aliases:CHOP; CEBPZ; CHOP10; CHOP-10; GADD153 Entrez GeneID:1649 Swissprot:P35638 clone:4E8E9 WB Predicted band size:19.2kDa Host/Isotype:Mouse IgG2a Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human DDIT3 (AA: 87-192) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide. Application IHC:1/200 - 1/1000 ICC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000