HDAC4抗体;HDAC4 Polyclonal Antib

Description Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. References 1. Biochem Biophys Res Commun. 2008 Dec 19;377(3):852-6. 2. Curr Top Med Chem. 2009;9(3):235-40. 3. Nucleic Acids Res. 2010 May;38(9):2813-24. Specification Aliases:HD4; HDACA; HA6116; HDAC-A; KIAA0288; HDAC4 Entrez GeneID:9759 Swissprot:P56524 clone:7B2 WB Predicted band size:119kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human HDAC4 expressed in E. Coli. Formulation:Purified antibody in PBS containing 0.05% sodium azide. Application WB:1/500 - 1/2000 ELISA:1/10000