CHD3抗体;CHD3 Polyclonal Antibod

Description This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. References 1. vi r us Res. 2003 Dec;98(1):83-91. 2. Mol Cell. 2004 Sep 24;15(6):853-65. 3. J Biol Chem. 2008 Dec 12;283(50):34976-82. Specification Aliases:ZFH; Mi-2a; Mi2-ALPHA; CHD3 Entrez GeneID:1107 Swissprot:Q12873 clone:2G4 WB Predicted band size:226kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human,Mouse Immunogen:Purified recombinant fragment of human CHD3 expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide. Application WB:1/500 - 1/2000 IHC:1/200 - 1/1000 ICC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000