CYP1A1抗体;CYP1A1 Polyclonal Ant

Description This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. References 1. Cancer Res. 2009 Apr 1;69(7):2956-65. 2. Drug Metab Lett. 2009 Jan;3(1):18-27. Specification Aliases:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX Entrez GeneID:1543 Swissprot:P04798 clone:6G5 WB Predicted band size:58kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human CYP1A1 expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application IHC:1/200 - 1/1000 ELISA:1/10000