SDHB抗体;SDHB Polyclonal Antibod

Description Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. References 1.Endocrine. 2017 Sep;57(3):512-517. 2.J Natl Cancer Inst. 2016 Jan;108(1). Specification Aliases:IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP Entrez GeneID:6390 Swissprot:P21912 clone:2B2B1 WB Predicted band size:31.6kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human SDHB (AA: 29-280) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application IHC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000