ATP2A1抗体;ATP2A1 Polyclonal Ant

Description This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. References 1.Biochem Biophys Res Commun. 2012 Jun 29;423(2):212-7. 2.Mol Genet Metab. 2013 Sep-Oct;110(1-2):162-9. Specification Aliases:ATP2A; SERCA1 Entrez GeneID:487 Swissprot:O14983 clone:4F11F6 WB Predicted band size:110kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human,Mouse,Monkey Immunogen:Purified recombinant fragment of human ATP2A1 (AA: 487-631) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application WB:1/500 - 1/2000 ELISA:1/10000