CDC27抗体;CDC27 Polyclonal Antib

Description Cdc27 shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. It is a component of the Anaphase Promoting Complex (APC), which is composed of eight protein subunits and is highly conserved in eucaryotic cells. The APC catalyzes the formation of the cyclin B ubiquitin conjugate that is responsible for the ubiquitin mediated proteolysis of B type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. References 1. Mol Cell Biol. 2004 May;24(9):3577-87. 2. J Biol Chem. 2004 Oct 1;279(40):42128-38. Specification Aliases:APC3; HNUC; ANAPC3; CDC27Hs; D0S1430E; D17S978E; Entrez GeneID:996 Swissprot:P30260 clone:5C12 WB Predicted band size:91kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human CDC27 expressed in E. Coli. Formulation:Ascitic fluid containing 0.03% sodium azide. Application IHC:1/200 - 1/1000 ELISA:1/10000