PAWR抗体;PAWR Polyclonal Antibod

Description Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor. References 1. J Biol Chem. 2004 Jul 2;279(27):28266-75.2. Exp Hematol. 2004 Jul;32(7):649-56.3. Mol Cell Biol. 2005 Feb;25(3):1146-61.4. Psychiatr Genet. 2006 Oct;16(5):193-6. Specification Aliases:PAWR Entrez GeneID:5074 Swissprot:Q96IZ0 clone:3G9H7 Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of PAR4(aa1-330) expressed in E. Coli. Formulation:Ascitic fluid containing 0.03% sodium azide. Application WB:1/500 - 1/2000 IHC:1/200 - 1/1000 ELISA:1/10000