CDH1抗体;CDH1 Polyclonal Antibod

Description E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues. References 1. Nat Genet. 2009 Dec;41(12):1330-4. 2. Zhonghua Zhong Liu Za Zhi. 2009 Jul;31(7):515-9. 3. J Biol Chem. 2010 Feb 26;285(9):6658-69. Specification Aliases:UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1 Entrez GeneID:999 Swissprot:P12830 clone:7H12 WB Predicted band size:135kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human,Mouse,Monkey Immunogen:Purified recombinant fragment of human CDH1 expressed in E. Coli. Formulation:Ascitic fluid containing 0.03% sodium azide. Application WB:1/500 - 1/2000 IHC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000