ADORA2A抗体;ADORA2A Polyclonal A

Description This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. References 1.Mol Neurobiol. 2015 Aug;52(1):664-78. 2.J Psychiatr Res. 2014 Apr;51:49-59. Specification Aliases:A2aR; RDC8; ADORA2 Entrez GeneID:135 Swissprot:P29274 clone:6A6G11 WB Predicted band size:44.7kDa Host/Isotype:Mouse IgG2a Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human ADORA2A (AA: 274-412) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application ICC:1/100 - 1/500 FCM:1/200 - 1/400 ELISA:1/10000