PTPRM抗体;PTPRM Polyclonal Antib

Description The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. References 1.PLoS One. 2012;7(11):e50183. 2.Exp Lung Res. 2011 Aug;37(6):327-43. Specification Aliases:RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU Entrez GeneID:5797 Swissprot:P28827 clone:1H6D10 WB Predicted band size:163.7kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human PTPRM (AA: extra 565-742) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application ELISA:1/10000