GCK抗体;GCK Polyclonal Antibody

Description Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). References 1. Mol Endocrinol. 2009 Dec;23(12):1983-9. 2. Int J Mol Med. 2009 Aug;24(2):233-46. Specification Aliases:GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3 Entrez GeneID:2645 Swissprot:P35557 clone:4G6 WB Predicted band size:52kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human GCK expressed in E. Coli. Formulation:Ascitic fluid containing 0.03% sodium azide. Application ELISA:1/10000