IL15RA抗体;IL15RA Polyclonal Ant

Description This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010] References 1.J Cancer Res Ther. 2018 Sep;14(Supplement):S648-S655. 2.BMC Cancer. 2017 Sep 11;17(1):640. Specification Aliases:IL15RA Entrez GeneID:3601 Swissprot:Q13261  clone:5F10D9 WB Predicted band size:28.2kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human CD215 (AA: extra 31-205) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application WB:1/500 - 1/2000 ELISA:1/10000