HDAC3抗体;HDAC3 Polyclonal Antib

Description HDAC3: histone deacetylase 3, also known as HD3, RPD3, RPD3-2. Entrez Protein NC_000005. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. References 1. Folia Biol (Praha). 2006;52(1-2):21-33. 2. Mol Cell Biol. 2007 Feb;27(4):1280-95. 3. Mol Carcinog. 2008 Feb;47(2):137-47. Specification Aliases:HD3; RPD3; RPD3-2 Entrez GeneID:8841 Swissprot:O15379 clone:7G6C5 WB Predicted band size:48.8kDa Host/Isotype:Mouse IgG2a Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human HDAC3 (aa224-428) expressed in E. Coli. Formulation:Ascitic fluid containing 0.03% sodium azide. Application WB:1/500 - 1/2000 ICC:1/200 - 1/1000 ELISA:1/10000